Based on Wootton's Bipolar in Order Seminar that he has developed over the past two years, this book focuses on the positive approach to the bipolar condition. It is about coming to an acceptance of oneself while striving to become a better person.

Drawing from historical and literary examples ranging from the lives of the saints to Buddhist parables to pop-culture heroes like the X-Men, "The Depression Advantage" demonstrates that spiritual and emotional pain can actually be a catalyst for personal growth and transcendent understanding.