Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments. Statistical methods play a key role in all stages of these trials, including their justification, design, and analysis. This second edition of Introduction to Randomized Controlled Clinical Trials provides a concise presentation of the principles applied in this area. It details the concepts behind randomization and methods for designing and analyzing trials and also includes information on meta-analysis and specialized designs, such as...

-In our time when so much emphasis is on the quick and the facile, the glamorous and the trendy, John Matthews offers something deep and lasting. He bridges the ancient wisdoms of our past and the possibilities of our future. He calls himself a shaman, but I call him a sage. And as you read the treasures in this book, I believe you will as well.- David Spangler