Despite the prevalence of both pharmaceutical and behavioral approaches to encourage cessation, over a billion people still indulge in tobacco. Even in the U.S., where tobacco use is considered a clearly treatable and socially regrettable condition, a significant percentage of individuals remain resistant to treatment modalities. It is believed that the problem lies with the availability, the effectiveness, and the tolerance of the treatments. Thus, the development of new and more effective medications for treating nicotine dependence is an area of significant therapeutic importance, and one...