Enormous advances in our knowledge of genetic contributions to aging and disease, and in our understanding of the potential for manipulation of the aging process, have taken place during the past 20 years. This is the first volume in decades to consolidate this research in one place. It provides a broad and current overview of the most promising advances in genetic research on aging, current understanding of genetic contributions to the basic processes of aging, and age-related disease. The Review focuses on the aging process from lower organisms to man, and is organized in ascending order...