In 23 papers from an international conference in Newport Beach, California, February 1992, immunologists and molecular biologists focus on the role interactions among the cells play in lymphocyte activation and immune regulation. The general topics are cell receptors and T-cell activation; T-cell de

Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches...