Interest in the biological effects of ionising radiation closely followed the identification of such radiation. The realisation that DNA is the site of genetic infonnation in cells subsequently focussed attention on DNA as an important target in the lethal and mutagenic effects of ionising radiation. Thus radiation effects upon DNA became an important area for fundamental scientific studies by radiation biologists, chemists and physicists. To a first approximation, the concerns of the three disciplines can be divided by time scales: the physical process of energy deposition from photon or...

This Workshop, under the auspices of the NATO Advanced Research Workshop program, was organised to review the current status of research into redox-activated compounds particularly bioreductive drugs, and their applications in various fields of medicine, both as diagnostic and therapeutic agents. The Workshop brought together key workers in this currently expanding field of research, i.e. clinici- ans, pharmacologists, biochemists and molecular scientists. The programme consisted of several sections including general review lectures, presentations of laboratory-based and clinical research,...