The proceedings of the September 1990 NATO Advanced Research Workshop comprise papers and poster abstracts in four sections: general overview; the molecular basis of patterning (introduction; pattern of pattern; retinoids and other factors); the extracellular matrix and limb development (overview; c

Following pioneering work by Harrison on amphibian limbs in the 1920s and by Saunders (1948) on the apical ridge in chick limbs, limb development became a classical model system for investigating such fundamental developmental issues as tissue interactions and induction, and the control of pattern formation. Earlier international conferences, at Grenoble 1972, Glasgow 1976, and Storrs, Connecticut 1982, reflected the interests and technology of their time. Grenoble was concerned with ectoderm-mesenchyme interaction, but by the time of the Glasgow meeting, the zone of polarizing activity (ZPA)...