close circle of anaesthetic scientists but, with the help of computer technology, has greatly influenced the practice of the modern clinical anaesthesiologist. The efforts of anaesthesiologists, pharmaceutical companies, and the development of the internet has lead to a situation that now almost every anaesthesiologist can be in close contact to anaesthetic pharmacology computer simulation pro- grams and target controlled infusion devices. These two tools allow us to in- crease our understanding and improve the controllability of anaesthetic drug administration, on site, in the operating...