Advances in computers and biotechnology have had a profound impact on biomedical research, and as a result complex data sets can now be generated to address extremely complex biological questions. Correspondingly, advances in the statistical methods necessary to analyze such data are following closely behind the advances in data generation methods. The statistical methods required by bioinformatics present many new and difficult problems for the research community.

This book provides an introduction to some of these new methods. The main biological topics treated include sequence...

Population genetics occupies a central role in a number of important biological and social undertakings. It is fundamental to our understanding of evolutionary processes, of plant and animal breeding programs, and of various diseases of particular importance to mankind.

This is the first of a planned two-volume work discussing the mathematical aspects of population genetics, with an emphasis on the evolutionary theory. This first volume draws heavily from the author's classic 1979 edition, which appeared originally in Springer's Biomathematics series. It has been revised and...

This book describes the probability theory associated with frequently used statistical procedures and the relation between probability theory and statistical inference. The first third of the book is dedicated to probability theory including topics relating to events, random variables, and the Central Limit Theorem. Statistical topics then include parameter estimation with confidence intervals, hypothesis testing, chi-square tests,ttests, and several non-parametric tests. Flow charts are frequently used to facilitate an understanding of the material considered. The examples and problems in...