McLeod discovered that atypical depression is triggered by insulin resistance, and that supplemental chromium can bring fast, safe, effective relief in people who had suffered from depression for as long as twenty or thirty years.

Dr. MccLeod's discovery that chromium, an insulin-sensitizing trace mineral, was more effective and faster acting in some patients than even the strongest antidepressant drugs, was met with skeptisim when first announced. Dr. McLeod eventually derived and explanation for chromium's powerful therapeutic effect and the medical and scientific communites have begun to confirm his pioneering findings.