The stratum corneum is a magnificent example of the successful adaptation of a tissue. Its efficient function is a prerequisite for life itself. We depend on its control of the movement of water through the skin and on its protective role in the prevention of penetration by pathogens or harmful substances. Apart from its functional importance, there is no escaping the fact that the most common skin disorders (psoriasis, eczema, inherited disorders of keratinization, acne) are 'characterised by abnormal keratinization and or scaliness. Despite all this, understanding of its chemistry,...

Bei der Behandlung von Hauterkrankungen spielt die ortliche Anwendung von Arzneimitteln eine zentrale Rolle, alternativ kommt aber auch immer haufiger eine innerliche oder systemische Therapie in Betracht. In vielen Fallen gilt es, topische und systemische Therapie miteinander in sinnvoller Weise zu verbinden. Dieses Buch berucksichtigt beide Therapieformen in adaquater Weise und erweist sich aufgrund seiner knappen, pragnanten Darstellung als sehr praxisorientiert. Auch der Allgemeinmediziner, der zunehmend mit dermatologischen Fragestellungen konfrontiert wird, findet in diesem Buch...

Twenty-five years have elapsed since the first publication of this book. The growth of basic knowledge since then has been both enormous and momentous. This has been a joyous enterprise for us. Our ability to treat acne and rosacea ef- fectively has outpaced the vastly expanded understanding of their etiologies. Acne today is not only an eminently treatable disease; in some cases, for exam- is actually curable. We think that no case is so severe as to pIe acne conglobata, it be beyond help with the array of diverse drugs now available. Treatment failure is really physician failure. Prevention...