The Second International Conference on High-Performance Computing and Appli- tions (HPCA 2009) was a follow-up event of the successful HPCA 2004. It was held in Shanghai, a beautiful, active, and modern city in China, August 10-12, 2009. It served as a forum to present current work by researchers and software developers from around the world as well as to highlight activities in the high-performance c- puting area. It aimed to bring together research scientists, application pioneers, and software developers to discuss problems and solutions and to identify new issues in this area. This...