This reference presents a comprehensive overview of the state-of-the-art in cell culture technology. The book describes manipulations and the genetic engineering of cells for the production of biotechnology products, tissue engineering, and cell-based therapies. Each expertly written chapter covers research, principles, and equipment currently affecting advances in the discovery of genes, host cell selection, cloning and gene amplification, bioreactor design, protein purification, optimization and scale-up, product quality, and facility design--showcasing the importance of genomic and...