Biomedical research is at a critical point at present. The research has led to an enormous amount of data and models describing these data, but - proachesforapplication, formalizationand integrationof this knowledgefrom the molecular to the system level are still topics of ongoing research and c- tainly far from fully developed. Also in cardiology the di?erent anatomical and physiological constituents as well as the coupling between them are being researchedin increasing detail and areoften described using computer-based models. But for this domain an integrative framework is still missing....