This volume stems from the eighth international symposium and workshop entitled -Hematopoietic Stem Cells VIII- held hosted by the University of Tuebingen, Germany in the fall of 2011. The meeting was designed to bring 30 leading scientists together to discuss the state-of-the-art in the field of hematopoietic stem cells. Topics reviewed in this volume include: differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches; hematopoietic stem cell expansion; TIM-3 as a therapeutic target for malignant stem cells in acute myelogenous leukemia; regulatory factors...