This book presents new and powerful advanced statistical methods that have been used in modern medicine, drug development, and epidemiology. Some of these methods were initially developed for tackling medical problems. All 29 chapters are self-contained. Each chapter represents the new development and future research topics for a medical or statistical branch. For the benefit of readers with different statistical background, each chapter follows a similar style: the explanation of medical challenges, statistical ideas and strategies, statistical methods and techniques, mathematical remarks...

The book aims to provide both comprehensive reviews of the classical methods and an introduction to new developments in medical statistics. The topics range from meta analysis, clinical trial design, causal inference, personalized medicine to machine learning and next generation sequence analysis. Very broad topics in medical statistics are addressed. Not only is a rigorous theoretical background emphasized but motivation, applications, examples and computational aspects of the related statistical methods are given adequate weightage. The volume thus provides a convenient starting point for...