Much of our knowledge regarding the biology of nitric oxide (NO), a key biological signaling molecule, has come from the use of synthetic agents that release NO or a redox-related species. Despite the proliferation of NO-donor complexes, rates of NO release and the redox state of the liberated NO from these compounds are neither predictable nor controllable to any practical extent. C-nitroso compounds comprise a unique class of NO donors from which the rate of NO release and the oxidation state of the liberated NO can be precisely controlled by the nature of the substituents geminal to the...
Much of our knowledge regarding the biology of nitric oxide (NO), a key biological signaling molecule, has come from the use of synthetic agents that ...