This volume is the eleventh published from a conference sponsored by the World Organization for Specialized Studies on Diseases of the Esophagus (OESO) and the second to be published in Annals. As with the preceding publications, the present one follows a world conference of OESO; in this case, a conference entitled -Reflux disease, from LES to UES, and beyond, - held in Como, Italy. Collectively, the papers present the wealth of ideas and knowledge covered by the four-day OESO conference on esophagology, with each paper showcasing the responses provided by top experts to precise...