The subject of Pediatric Bone Marrow Transplantation is reviewed in this issue of Pediatric Clinics. Guest Editors Drs. Max Coppes, Terry Fry, and Crystal Mackall have assembled a panel of experts who offer reviews on topics including Allogeneic BMT for leukemia, GVL in pediatric leukemia, Stem cell source and outcome following BMT in children, Acute GVHD in children, Chronic GVHD in children, BMT for Hemoglobinopathies, BMT for immunodeficiency, BMT for rheumatologic disorders and other benign diseases, Autologous and Allogeneic BMT for solid tumors, Late effects following BMT, Cell...

This issue highlights some of the exciting new developments in pediatric oncology and hematology.? Three articles are devoted to pediatric leukemia, which remains the most common form of pediatric cancer.? Specifically, articles address ALL, AML, and leukemia in patients with Down syndrome. Other articles that address pediatric oncology include CNS tumors and neuroblastoma as well as advances in cancer immunotherapy. A very interesting article addresses the challenges experienced by adults who survived a childhood cancer. The hematology articles in this issue cover aspects that most...

Dr. Coppes and his co-Editors have created a comprehensive table of contents that addresses the full spectrum of food allergies in children. Articles are presented to be most useful to pediatricians, as the issue begins with the clinical presentation and epidemiology of food allergy, and then progresses to the diagnostic testing and pahthophysiology.? Articles are also included that are devoted to specific types of food allergy, dairy, soy, egg, peanut, and tree nut. Finally, articles are also devoted to living with food allergies, management of allergies in schools and camps, and therapies...

WT1 is a DNA Binding Protein Containing Four C2H2 Zinc Fingers ...89 The DNA Binding Domain ofWT1 ********************************************** *** 90 WT1 Inhibits Tag and SV40 Origin Dependent Replication ...97 WT1 is an Unusual C2H2 Zinc Finger Protein ...98 WT1 is a Transcriptional Regulator ...99 Possible Downstream Targets ofWT1 Transcriptional Regulation ...103 Protein-Protein Interactions Involving WT1 ...104 Other Factors that May Contribute to or Modify the Cellular Function ofWT1 ...104 WT1 and Apoptosis ...106 Conclusion ...107 7. Naturally Occurring Mutations in the WTJ Gene...