Reactive Search integrates sub-symbolic machine learning techniques into search heuristics for solving complex optimization problems. By automatically adjusting the working parameters, a reactive search self-tunes and adapts, effectively learning by doing until a solution is found. Intelligent Optimization, a superset of Reactive Search, concerns online and off-line schemes based on the use of memory, adaptation, incremental development of models, experimental algorithms applied to optimization, intelligent tuning and design of heuristics.