Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the...

Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing.

This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to...

Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation.

This book details the latest technical and technological developments in the growing field of noninvasive diagnosis in clinical dermatology. It provides information on the practical and technical characteristics of a wide range of equipment and methods.

Cosmetic Science and Technology: Theoretical Principles and Applications covers the fundamental aspects of cosmetic science that are necessary to understand material development, formulation, and the dermatological effects that result from the use of these products. The book fulfills this role by offering a comprehensive view of cosmetic science and technology, including environmental and dermatological concerns.

As the cosmetics field quickly applies cutting-edge research to high value commercial products that have a large impact in our lives and on the world's economy,...

Various areas of acne are addressed, including acne severity grading, the assessment of general health and quality of life in patients with acne, and the effect of automated online counseling on clinical outcomes and quality of life among adolescents with acne vulgaris.

The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field.