In Singular Intimacies, which the New England Journal of Medicine said captured the "essence of becoming and being a doctor, " Danielle Ofri led us into the hectic, constantly challenging world of big-city medicine. In Incidental Findings, she's finished her training and is learning through practice to become a more rounded healer.

"Ofri's thoughtful and honest second book—the title is inspired by her realization, during her own amniocentesis, that conditions that seem minor to doctors are monumental when they happen to...