Epidemics and Enslavement is a groundbreaking examination of the relationship between the Indian slave trade and the spread of Old World diseases in the colonial southeastern United States. Paul Kelton scrupulously traces the pathology of early European encounters with Native peoples of the Southeast and concludes that, while indigenous peoples suffered from an array of ailments before contact, Natives had their most significant experience with new germs long after initial contacts in the sixteenth century. In fact, Kelton places the first region-wide epidemic of smallpox in the 1690s and...

There is no question that European colonization introduced smallpox, measles, and other infectious diseases to the Americas, causing considerable harm and death to indigenous peoples. But though these diseases were devastating, their impact has been widely exaggerated. Warfare, enslavement, land expropriation, removals, erasure of identity, and other factors undermined Native populations. These factors worked in a deadly cabal with germs to cause epidemics, exacerbate mortality, and curtail population recovery.

Beyond Germs: Native Depopulation in North America challenges the...