Twenty five numbers of crabs (P. sanguinolentus) were collected from Parangipettai fish market. Paenibacillus sp were isolated from the gut of crabs. Then the isolated colonies were characterized for phenotypic and biochemical properties for identification. Out of twenty five crabs, twenty one showed the presence of E.coli while only four crabs showed the presence of Paenibacillus sp. Among these isolates Paenibacillus sp. showed drug resistance to 11 antibiotics and sensitiveness to 2 antibiotics, whereas E.coli was found to be the sensitive to all the 13 antibiotics which were provided in...