This volume collects presentations from the international workshop on local cohomology held in Guanajuato, Mexico, including expanded lecture notes of two minicourses on applications in equivariant topology and foundations of duality theory, and chapters on finiteness properties, D-modules, monomial ideals, combinatorial analysis, and related topics. Featuring selected papers from renowned experts around the world, Local Cohomology and Its Applications is a provocative reference for algebraists, topologists, and upper-level undergraduate and graduate students in these disciplines.