Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their...
Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cell...
The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a...
The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleto...
The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a...
The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, ...
Drawing on a wide range of primary sources, this volume covers the period when coal was the pivot on which British economic pre-eminence rested. It reasses widely accepted generalizations regarding the industry's economic development and explores its social ramifications.
Drawing on a wide range of primary sources, this volume covers the period when coal was the pivot on which British economic pre-eminence rested. It re...
Massive public protests have had a prominent presence at the turn of the millennium, with many thousands of protestors controlled by small, yet, increasingly specialized police forces. Investigating the ways in which police practices have evolved in relation to labour strikes and protests, Intelligent Control examines the means by which police forces have developed more coercive and consent-based approaches to regulating social unrest.
Willem de Lint and Alan Hall argue that police forces have been gradually adapting public order operations to match or reflect wider trends in...
Massive public protests have had a prominent presence at the turn of the millennium, with many thousands of protestors controlled by small, yet, in...
This is a cookbook and documenty of Appalachian food. It is a unique blend of the recipes brought by settlers and the native people-Cajun, French, German, Scots, escaped slaves and Cherokee. This cuisine is a merging of all of the cultures from the people that settled in the mountains. It is born of fresh ingredients, wild plants and game. It fed small farmers with little ground, which might support an essential pig, and maybe a cow. They hunted a great deal and gathered what was wild and grew other crops, notably corn. The mountaineers were cash poor but masters of self sufficiency. They...
This is a cookbook and documenty of Appalachian food. It is a unique blend of the recipes brought by settlers and the native people-Cajun, French, Ger...
This book provides an up-to-date, compact but comprehensive review of chemical skin injuries, differentiating them from thermal skin burns. After an introductory chapter on the history of chemical skin injuries and the scope of the problem, the anatomy, histology, physiology, and immunology of normal skin are described. Mechanisms involved in chemical penetration of normal skin are explained, and the effects of damaged skin on chemical penetration are analyzed. The remainder of the book discusses a variety of clinically relevant aspects, such as the different forms of chemical skin injury,...
This book provides an up-to-date, compact but comprehensive review of chemical skin injuries, differentiating them from thermal skin burns. After an i...
'I believe that I will make a better future, ' is a popular notion of political, religious, educational and business leaders. To believe is to think that something is true or real. This does not mean it is true. Beliefs become opinions, which are fixed and non-negotiable. It is difficult to exchange ideas when a sentence starts with 'I believe' and there is no backup of fact. The belief is irrelevant and the behaviour will determine the state of the future. Western leadership drowns in greed, entitlement, belief and gross ignorance, while those who follow, scrabble for the remnants of bad...
'I believe that I will make a better future, ' is a popular notion of political, religious, educational and business leaders. To believe is to think t...
This book provides a comprehensive review of chemical skin injuries, differentiating them from thermal skin burns. It describes effective preventive measures and explains how to mitigate the effects of chemical skin exposures in industrial settings.
This book provides a comprehensive review of chemical skin injuries, differentiating them from thermal skin burns. It describes effective preventive m...
