KLF6 is a ubiquitously expressed Kruppel-like transcription factor whose role in vitro and in vivo role has not been fully identified. Like other members of the Kruppel-like family, KLF6 contains a conserved C-terminal three zinc finger DNA-binding domain (C2H2 motifs) and a unique N-terminal transactivation domain. KLF6 directly binds DNA at GC box promoter elements. Transcriptional targets of KLF6 include collagen 1, transforming growth factor beta 1 (TGF 1), types I and II TGF receptors, urokinase type plasminogen activator (uPA), and the human immunodeficiency virus long terminal repeat...
KLF6 is a ubiquitously expressed Kruppel-like transcription factor whose role in vitro and in vivo role has not been fully identified. Like other memb...
Kruppel-like factors (KLFs) are attracting great attention across a wide spectrum of biological sciences and medicine because of their remarkable biological potency and the diversity of roles they play in the physiological and pathological changes of cells and tissues. This book is a comprehensive compendium of the latest research on the molecular mechanisms of KLFs, describing their roles in transcriptional regulation, cellular differentiation and development, the pathogenesis of the liver and cardiovascular systems and cancer, and generation of ES cells and iPS cells. As the only concise...
Kruppel-like factors (KLFs) are attracting great attention across a wide spectrum of biological sciences and medicine because of their remarkable b...
