This volume constitutes the strictly refereed post-workshop proceedings of the 5th International Workshop on Languages, Compilers, and Run-Time Systems for Scalable Computing, LCR 2000, held in Rochester, NY, USA in May 2000. The 22 revised full papers presented were carefully reviewed and selected from 38 submissions. The papers are organized in topical sections on data-intensive computing, static analysis, openMP support, synchronization, software DSM, heterogeneous/-meta-computing, issues of load, and compiler-supported parallelism.