Biophysical studies in the 1950ies and 1960ies led to the realization that the water permeability of certain biological membranes must be due to the presence of water transporting proteins. This hypothesis was confirmed in 1991 and 1992 with the pioneering discovery of the first molecular membrane water channel, CHIP28, by Agre and coworkers. This integral membrane protein, which is abundant in the erythrocyte membrane and in many epithelial cells, is now called aquaporin-1 or AQP1. Thus the terms water channel or aquaporin are synonymous.
In July 2000 more than 200 researchers came...

Since the discovery of Aquaporin-1 (AQP1) as a water channel, many studies have revealed the importance of aquaporins in mammalian physiology and pathophysiology as well as plant and microbial biology. The studies have also shown aquaporins as potential drug targets and targets for improving crop properties.

Written by an international group of contributors at the forefront of the field, Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery presents the latest research advances in aquaporins and other major intrinsic protein (MIP)...

In chapter 1, the basic assumptions of the random vibration theory are emphasized. In Chapters 2 and 3, pertinent results of stochastic variables and stochastic processes have been indicated. Chapter 4 deals with the stochastic response analysis of single degrees-of-freedom, multi-degrees-of-freedom and continuous linear structural systems. In principle, an introductory course on linear structural dynamics is presupposes. However, in order to make this textbook self-contained, short reviews of the most important results of linear deterministic vibrationtheory have been included in the start...