This collection of critical essays explores 12 keywords central in Latin American and Caribbean Studies: indigenismo, Americanism, colonialism, criollismo, race, transculturation, modernity, nation, gender, sexuality, testimonio, and popular culture. The central question motivating this work is how to think-epistemologically and pedagogically-about Latin American Studies as a field that has taken different historical and institutional trajectories across the Caribbean, Latin America, and the United States.