Douglas A. Smith Charlotte Allerton Amit S. Kalgutkar
In this new edition of a bestseller, all the contents have been brought up-to-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. New chapters on prodrugs, antitumor drugs and active metabolites, among other topics, have been added. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic...
In this new edition of a bestseller, all the contents have been brought up-to-date by addressing current standards and best practices in the assessmen...