Collected in this volume are the works of Paul Grice, who not only presents a fascinating metaphysical defense of value but also provides a metaphysical foundation for value. Value judgments are viewed as objective; they are part of the world we live in, but are nonetheless constructed by us. We inherit, or seem to inherit, the Aristotelian world in which objects and creatures are characterized by what they are supposed to do. We are thereby enabled to evaluate by reference to function and finality. The most striking part of Grice's position, however, is his contention that the legitimacy of...

This book discusses the latest advances and developments in toxicity and drug testing. It encompasses rising technologies (3D cultures, next generation sequencing, profiling technologies, etc.), available techniques and models to assess potential drugs and medicinal plants with reference to drug testing and advancement, and toxicity. Contributions have been made in this book by veterans from across the world. The aim of this book is to serve as a valuable source of information for physicians as well as scientists who are directly dealing with drugs/medicines and human life.

Present-day drug design and testing includes experimental in-vitro and in-vivo measurements of the drug candidate's adsorption, distribution, metabolism, elimination and toxicity (ADMET) properties in the initial stages of drug discovery. Just a poor percentage of the recommended drug candidates get the authorization of government and reach the market place. Disadvantageous pharmacokinetic properties, bad bioavailability and efficiency, negative side effects, poor solubility and toxicity matters are responsible for most of the drug failures confronted in the pharmaceutical industry. Authors...

Present-day drug design and testing includes experimental in-vitro and in-vivo measurements of the drug candidate's adsorption, distribution, metabolism, elimination and toxicity (ADMET) properties in the initial stages of drug discovery. Just a poor percentage of the recommended drug candidates get the authorization of government and reach the market place. Disadvantageous pharmacokinetic properties, bad bioavailability and efficiency, negative side effects, poor solubility and toxicity matters are responsible for most of the drug failures confronted in the pharmaceutical industry. This book...

This book primarily discusses the methods and techniques of virtual screening. CoMFA, Pharmacophore modeling, CoMSIA, QSAR analysis, molecular dynamics simulations and docking have been started to be employed at variable degrees in virtual screening for the purpose of uncovering novel bioactive hits. However, implementation of these methods needs integrative knowledge and experience. The book elucidates established methodologies and novel trends in this field with the aim of facilitating their use in drug discovery.