The book focuses on the latest discoveries on calreticulin, calnexin and other endoplasmic reticulum proteins. Calreticulin has been implicated to affect diverse cellular function and play a role in many pathologies including protein folding disorders, cardiac pathologies, cancer and autoimmunity. This book contains contributions from the world leaders in the area of endoplasmic reticulum function, protein folding, Calcium homeostasis and autoimmunity. It raises many intriguing questions about calreticulin, calnexin and the endoplasmic reticulum and gives a unique opportunity to realize the...

Calcium is a versatile carrier of signals regulating many aspects of cellular activity such as fertilization to create a new life and programmed cell death to end it. Calcium homeostasis is strictly controlled by channels, pumps and exchangers functioning as gates for calcium entry and release. Given that calcium is such a versatile messenger the field of calcium signaling is continuously and rapidly expanding. This book reviews the most recent developments in calcium signaling by leading experts in the field. It is a state-of-the-art summary of our present knowledge in this quickly growing...

The book focuses on the latest discoveries on calreticulin, calnexin and other endoplasmic reticulum proteins. Calreticulin has been implicated to affect diverse cellular function and play a role in many pathologies including protein folding disorders, cardiac pathologies, cancer and autoimmunity. This book contains contributions from the world leaders in the area of endoplasmic reticulum function, protein folding, Calcium homeostasis and autoimmunity. It raises many intriguing questions about calreticulin, calnexin and the endoplasmic reticulum and gives a unique opportunity to realize the...

This book is about calreticulin, a multifunctional calcium binding protein first discovered over 20 years ago. The protein has been described in various locations: endoplasmic reticulum, nuclear envelope, cytoplasmic granules, nucleus, cell surface and even secreted into the blood stream. This volume outlines the newly discovered functions for calreticulin including its control of calcium homeostasis, modulation of steroid-sensitive gene expression, control of viral RNA replication, modulation of nuclear transport, role in T lymphocyte activation and cytotoxic killing, chaperone function,...