The HIV/AIDS pandemic is the most devastating global public health crisis since the great plagues of the Middle Ages, with more than 14,000 new HIV infections and 8,000 deaths due to AIDS every day. Although successful vaccines have been developed for most common childhood diseases, the development of a vaccine against the AIDS virus is a much greater challenge. More than 20 years after the discovery of the virus, the goal of a licensed and globally accessible vaccine is still several years away. AIDS Vaccine Development reviews the scientific challenges that have impeded the search for an...

How is growth controlled in normal cells? How are the growth control mechanisms perturbed in cancer cells? This book provides an up-to-date description of research aimed at resolving these questions. It is organized into four sections, each containing a series of short reviews written by experts in the field. The general headings are: growth factors, receptors, and related oncogenes: transduction of mitogenic signals and ras oncogenes; nuclear oncogenes and regulation of gene expression; and multiple steps involved in malignant transformation. The articles emphasize concepts rather...