This monograph contains a description of the discovery and development of a new antisecretory therapy in the treatment of acid-related disea ses: omeprazole, the first proton pump inhibitor. The pharmacology of different proton pump inhibitors, the pharmaceutic delivery system and the clinical experience with proton pump inhibitors is reviewed. The book is aimed at a broad readership with an interest in the developme nt problems of this, at present, most commercially successful drug; th e pharmacology of a ttailor-madev drug for a specific target; the ther apeutic strategies in acid-related...