Principles and Practices of Method Validation is an overview of the most recent approaches used for method validation in cases when a large number of analytes are determined from a single aliquot and where a large number of samples are to be analysed. Much of the content relates to the validation of new methods for pesticide residue analysis in foodstuffs and water but the principles can be applied to other similar fields of analysis. Different chromatographic methods are discussed, including estimation of various effects, eg. matrix-induced effects and the influence of the equipment set-up....

Reliable and metrologically comparable results of quantitative analytical methods are essential to assure that decisions taken on their basis have meaning and context. Problems with combining measurement results, calculating their uncertainties and establishing metrological traceability can prove complicated and ambiguous for measurement scientists. Combining and Reporting Analytical Results discusses in detail the problems faced by scientists, and presents a variety of approaches across biological, chemical and environmental sciences to resolving these types of issues. Topics include:...