Discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of the most exciting developments in the field, such as Fragment-based methods, are described in this book.

The book describes the latest developments in technologies that can be used to obtain the 3-D structures including the high profile structural genomics approaches being utilised...

Examining discomfort s physical, emotional, conceptual, psychological and aesthetic dimensions, the contributors to this volume offer an alternate, cultural approach to the study of architecture and the built environment. By attending to a series of disparate instances in which architecture and discomfort intersect, On Discomfort offers a fresh reading of the negotiations that define architecture s position in modern culture. The essays do not chart comfort s triumph so much as discomfort s curious dispersal into practices that form modern life and what that dispersion reveals of...

Andrew Leach's Rome is the first book in Polity's exciting new 'Cities in World History' series, which aims to provide the general reader and traveller with historically informed companions to the world's greatest cities. Most city guides are good on practical details but very thin when it comes to recounting the histories of cities and contextualizing the buildings and sites for which they are famous. These new books from Polity bridge the gulf between guide and history by offering concise and accessible accounts written by some of the world's leading historians.

Rome...

Andrew Leach's Rome is the first book in Polity's exciting new 'Cities in World History' series, which aims to provide the general reader and traveller with historically informed companions to the world's greatest cities. Most city guides are good on practical details but very thin when it comes to recounting the histories of cities and contextualizing the buildings and sites for which they are famous. These new books from Polity bridge the gulf between guide and history by offering concise and accessible accounts written by some of the world's leading historians.

Rome...