Pui (U. of Tennessee Health Science Center) presents 42 papers that are devoted to identifying and discussing pivotal issues that might be resolved through better applications of current methods of leukemia management, rather than waiting for laboratory discoveries to drive change. Chapters look at

International experts not only review the state-of-the-art in managing children and adults with acute leukemia, but also debate the pros and cons of current controversial and problematic issues. The book summarizes the best diagnostic and treatment practices for acute leukemias in children, adolescents, and adults. Among the therapies discussed are methotrexate, asparaginase, antipurines, epipodophyllotoxins, hematopoietic stem cell transplantation, hematopoietic growth factors, and immunotherapy.