Due to a high incidence of anemia, critically ill patients are frequently transfused, with up to 40% of patients receiving a transfusion during their stay in the Intensive Care Unit. It has become increasingly clear that there is an association between transfusion and adverse outcomes, underlining the need for a careful assessment of the risks and benefits of a blood transfusion. In the last decade, there have been several large clinical trials that have studied red blood cell transfusion triggers in various ICU patient populations, allowing us to take a personalized approach to transfusion....