Our work began where the greatest classical morphologists left off; their best work was the start of ours. As our work progressed, the rigidity of basic, previous embryological principles was broken down as scientific knowledge advanced. At the same time, the molecular, biological characterization of the cell surface receptor systems progressed enormously with the invention of numerous monoclonal antibodies. Thus, thymology became once again very important because the thymus is the first and central organ of the human immunological system. Then, the question of immuno-neuroendocrine...

I. MOLECULAR BIOLOGY OF TUMORS.

1. Brain Tumors

1. Introduction

2. Medulloblastoma

3. Glial Tumors

2. Immunophenotypic Characterization of Infiltrating Poly- and Mononuclear Cells in Childhood Brain Tumors

1. Introduction

2. The Significance of Immunohistochemistry

3. Original Immunohistochemical Observations

4. Intermediate filaments (IFs)

5. Expression of Homeobox B3, B4, and C6 Gene Products

6. Cell proliferation

7. Epidermal growth factor (EGF) and its receptor (EGFR)

8. p53,...

I. OVERVIEW OF MAMMALIAN THYMIC DEVELOPMENT

1. Embryology of the Mammalian Thymus

II. HISTOGENESIS OF THE MAMMALIAN THYMUS

2. The Reticulo-Epithelial Cellular Network of the Mammalian Thymus

3. Neuroendocrine influence on thymic hematopoiesis via the reticulo-epithelial (RE) cellular network

4. Development of Lymphopoiesis as a Function of the Thymic Microenvironment

5. The Hassall's bodies

6. Thymic Accessory Cells, including Dendritic-Type Antigen Presenting Cells, Within the Mammalian Thymic Microenvironment

7. Involution of the Mammalian Thymus and its Role in...

I. MOLECULAR BIOLOGY OF TUMORS.

1. Brain Tumors

1. Introduction

2. Medulloblastoma

3. Glial Tumors

2. Immunophenotypic Characterization of Infiltrating Poly- and Mononuclear Cells in Childhood Brain Tumors

1. Introduction

2. The Significance of Immunohistochemistry

3. Original Immunohistochemical Observations

4. Intermediate filaments (IFs)

5. Expression of Homeobox B3, B4, and C6 Gene Products

6. Cell proliferation

7. Epidermal growth factor (EGF) and its receptor (EGFR)

8. p53,...

The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monogaph presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It would be of particular interest to members of the cancer research community, especially those who are actively involved in the study of basic and translational aspects of human cancer. Specifically, this volume includes authentic subject reviews by leading experts on the following...