The seminar for which the proceedings are published here evolved from a cooperative research program on bilinear systems and applications to immunology at the Oregon State University and at the University of Rome. The topics include more general forms of variable structure systems which may be divided into categories of mathematical system theory, economic applications and biological applications. Throughout the seminar there was emphasis on the integration of theory and app- cation. In most cases, theoretical derivations are motivated by their need to solve practical problems. In reading the...