Many effective analgesic drugs are available for the relief of acute pain, but their clinical use is widely regarded as being inadequate. The reasons cited for this include concern about the adverse effects of opioids and also insufficient adjustment of therapy to the patient's needs. Non-opioid anal- gesics are the staple drugs for mild to moderate pain and are generally better tolerated than opioid drugs. Differences exist, however, among the non-opioid analgesics which affect the choice of drug for individual pa- tients and specific acutely painful conditions. In an associated symposium of...
Many effective analgesic drugs are available for the relief of acute pain, but their clinical use is widely regarded as being inadequate. The reasons ...
There is no ideal analgesic and the most potent drug is not always the best because of its side-effects. Non-opioid analgesics, including the non-steroi dal anti-inflammatory drugs and the non-narcotic analgesics, play an im portant role in the relief of a wide spectrum of painful conditions, though they vary in efficacy and safety. This book reviews the role which non-opi oid analgesics play in the relitff of pain, particularly with regard to post operative and cancer pain. Emphasis is placed on the clinical indications for the non-acidic analgesic, dipyrone, and its relative safety in...
There is no ideal analgesic and the most potent drug is not always the best because of its side-effects. Non-opioid analgesics, including the non-ster...
Highlighting 15 selected chiral structures, which represent candidate or marketed drugs, and their chemical syntheses, the authors acquaint the reader with the fascinating achievements of synthetic and medicinal chemistry.
The book starts with an introduction treating the discovery and development of a new drug entity. Each of the 15 subsequent chapters presents one of the target structures and begins with a description of its biological profile as well as any known molecular mechanisms of action, underlining the importance of its structural and stereochemical features. This section...
Highlighting 15 selected chiral structures, which represent candidate or marketed drugs, and their chemical syntheses, the authors acquaint the rea...
