Monoclonal antibodies have had their impact on biochemical research for more than a decade. Besides their exuberant use as reagents, quite a number of diagnostic and therapeutic approaches have been followed, and an impressive number of technological improvements, e.g. humanization, recombinant miniantibodies, have been elaborated to strengthen the principles. With respect to clinical applications, the first generation of antibody "drugs" is yielding promising results while second and third generation antibody constructs are already underway. This book reviews the status of technological...