In the early 1980s the transtheoretical model of change was still in its infancy. Seminal publications were just appearing, but the model already seemed to hold such promise that we made it the organizing theme for the Third International Conference on Treatment of Addictive Behaviors (ICTAB-3), which convened in Scotland in 1984. That meeting gave rise to the first edition of this volume (Miller & Heather, 1986), which focused on processes involved in moving people from one stage to the next. With the volume still in print more than a decade later, we were approached by Plenum Press with the...

Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase).

Whereas the first...