Erwin Schrodinger's book What is Life?, which was originally delivered as a set of lectures at Trinity College, Dublin, is perhaps one of the most important scientific books of the twentieth century. It marked the beginning of molecular biology, and stimulated scientists such as Watson and Crick to explore and discover the structure of DNA. The novelty and appeal of What is Life? is that Schrodinger addressed the central problems of biology--heredity and how organisms use energy to maintain order--from a physicist's perspective. Fifty years later, at Trinity College, a number of outstanding...
Erwin Schrodinger's book What is Life?, which was originally delivered as a set of lectures at Trinity College, Dublin, is perhaps one of the most imp...
A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA motifs, found commonly in both viruses and bacteria. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. There is therefore great interest in targeting...
A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of micr...
