The field of stroke and cerebrovascular disease in children is one in which there has been much recent research activity, leading to new clinical perspectives. This book for the first time summarises the ?state of the art? in this field. A team of eminent clinicians, neurologists and researchers provide an up-to-the-minute account of all aspects of stroke and cerebrovascular disease in children, ranging from a historical perspective to future directions, through epidemiology, the latest neuroimaging techniques, neurodevelopment, co-morbidities, diagnosis and treatment. The authors? practical...

-This is clearly the most authoritative and contemporary statement of current knowledge yet published.-
from the Foreword by H. Sarnat

Tuberous sclerosis is the prototype of a category of malformations uniquely characterized by disturbances in cellular differentiation and growth. It presents with a complex association of different neurological phenotypes, including seizures, cognitive impairments and autism. It is important not only because it is a relatively common hereditary neurological disease with high morbidity, but because it has implications in other pathological...

A great deal is now known about neurofibromatosis type 1, particularly as a result of the identification of its causative gene by positional cloning. However, effective treatments for its resulting cosmetic disfigurement, impaired cognitive performance and even life-threatening malignancy remain elusive. As Dr. Korf remarks in his Foreword: "this book's cogent and thorough description of neurofibromatosis in children will take its place alongside other major clinical studies of the disorder. Dr. North] has tackled some of the more challenging issues, such as the basis for learning...

This book is an authoritative synthesis of the role of vitamin treatments in children with neurological disorders. It covers all the conditions seen in pediatric neurology that are treatable by vitamin supplementation and consists of up-to-date, concise reviews by an international group of experts in their specific fields. They cover biotinidase deficiency; the role of vitamins in the developing nervous system, mitochondrial disorders and autism; homocysteinuria; conditions responsive to vitamin E or riboflavin; disorders of folic acid and vitamin B12 metabolism; folinic acid responsive...