This book covers both the basic principles of contemporary mass spectrometry instrumentation as well as its application to problems in structural biochemistry. Its tutorial form serves as an introduction to those entering the field, and for established scientists who wish to apply mass spectrometry to structural problems. The expertly written chapters introduce and summarize the capabilities of sector, tandem sector, hybrid, time-of-flight, triple quadrupole, ion trap, and Fourier transform mass spectrometers. New methods, such as electrospray ionization, laser desorption, and high...