Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice

"The Theory of Response-Adaptive Randomization in Clinical Trials" is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these...