Until recently, the vascular system was perceived as inert, and immunology and vascular biology were seen as unrelated disciplines. However, research has now shown that much of the work of the immune system occurs within the vascular canals and there is constant interaction between the immunocompetent cells and the vessel wall. This volume summarizes the manifold interactions between the endothelium and the immune response system and includes important sections examining the immunopathology involved in various forms of vascular damage, particularly atherosclerosis.