This book is the first to address both the theoretical and practical issues which arise when describing the geographical distribution of disease and investigating apparent disease clusters. Requirements in terms of population data, disease incidence and mortality are considered and related to the scale at which a study is being carried out. Statistical methods are reviewed for large scale correlation studies, intermediate scale smoothing exercises, and small scale clustering investigations, and the problems of interpretation are discussed. Problems of measuring environmental exposures at...

Prostate cancer is by far the most common cancer in men and the second leading cause of death due to cancer. It comprises a mixed group of tumours displaying varying clinical behaviour: while some have a very aggressive course, others are rather indolent. Prevention of prostate cancer and discrimination between aggressive and indolent forms are important clinical goals and the acquisition of significant new evidence on means of achieving these aims makes this book particularly timely. A wide range of topics are covered by leading authorities in the field. The biology and natural history of...

Prostate cancer is by far the most common cancer in men and the second leading cause of death due to cancer. It comprises a mixed group of tumours displaying varying clinical behaviour: while some have a very aggressive course, others are rather indolent. Prevention of prostate cancer and discrimination between aggressive and indolent forms are important clinical goals and the acquisition of significant new evidence on means of achieving these aims makes this book particularly timely. A wide range of topics are covered by leading authorities in the field. The biology and natural history of...